Agchimedes

Sustained Therapies

Novel Phage-Based Platform for Robust and Sustainable Solutions to Bacterial Diseases in Livestock and in Aquaculture

About Sustained Therapies

Sustained Therapies is an innovative biotech company based in Rehovot Israel, focused on providing end-to-end solutions for fighting bacterial diseases in agriculture, animal husbandry, aquaculture, across the food supply chain.

The company recognizes the growing need for sustainable solutions to combat bacterial diseases in the era of both climate change and of increasing AMR antimicrobial resistance. Especially to antibiotics.

The Problem:

Disease-carrying vectors spread rapidly posing a direct threat to global food security

Globalization

Globalization, and increased human interactions drive disease spread

AMR

AMR poses a threat to both animal and human health as resistant pathogens spread throughout the entire food chain posing a danger to both animal protein production and to its consumers

Climate Change

Climate change directly impacts on the rate of bacterial disease spread by creating conditions more suitable to the pathogens thus accelerating their spread

Emerging and re-emerging diseases

Emerging and re-emerging diseases in livestock are a significant concern

Emerging and Re-emerging Diseases

Vibriosis

Vibriosis spp. are the cause of bacterial diseases in fish and shrimps that can results in complete loss of production cycles and high economic losses to producers

Salmonella

Salmonella and Campylobacter in poultry are the two most important causes of poultry disease outbreaks in consumers entailing a significant cost to economies, adding to the health burden with tens of thousands of cases requiring hospitalization and also causing thousands of deaths annually

Sustained Therapies’ vision

Innovative and affordable bacteriophage-based solutions to combat bacterial diseases.

Sustained Therapies is focused on creating sustainable solutions for antimicrobial resistance AMR in agriculture.

Based on the scale and urgency of the problem, we were inspired by the potential of bacteriophages as a targeted, effective and environmentally friendly solutions

Blue Virus lap illustration
tunes with plants in a lab

The Solution

Novel phage-based platform for robust and sustainable solutions to bacterial diseases

Cost-effective PHAGE BASED

High titer, cost- effective, scaled up industrial phage production platform

LONG LIFE phage formulations

Phage-based cocktails with extended and superior shelf life in the field

Unique patented FORMULATION technology

Bacteria floating with blue background
Phage red

Value Proposition

A platform solution for multiple markets

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Enhanced Product Stability

Our groundbreaking production process has been validated demonstrate remarkable stability

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Stability Of Phage Cocktail Lysate

Our methods have produced an ultra-stable phage cocktail lysate at room temperature, showing superiority over traditional liquid fermentation processes

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Cost-Effective Production Process

We've succeeded in producing one liter of highly concentrated phages at titers of at least 10^11 pfu/ml with no need for ultrafiltration

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In-house Bacteria & Phage Bank

We have successfully established a robust in-house bacteria and phage bank.

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Novel Formulations

Our novel formulation enables us to further increase shelf life of our products allowing them to remain stable under various extreme conditions

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Simplified Logistics

Our phage lysate and formulations can be shipped and stored at room temperatures and do not require refrigeration

A platform solution for multiple markets

The Applications

Poultry Biocontrol

Bacteriophages and their derivatives are a novel and environmentally-friendly solution for the control of the key foodborne pathogens in Poultry – Salmonella and Campylobacter.

Enterococcus cecorrum has also become a major problem for the poultry industry,  becoming a significant cause of morbidity and mortality in broiler breeders.  . Cocktails of up to five highly specific phages could effectively control each of the above diseases, improving the safety of poultry to consumers and also improving feed conversion ratios and weight gain in broiler production.  

small yellow chickens
fish at sea aquaculture

Aquaculture Biocontrol

Bacteriophages targeting bacterial disease in commercial fish and shrimp production systems can easily and effectively replace antibiotics as a viable and affordable alternative and also guarantee to the consumer, disease-free, safe-to-eat fish and shrimps.

The Team

Jonathan Henen

Jonathan Henen

CEO 

 Over 40 years experience in Agronomy. Diverse & multidisciplinary knowledge in agriculture & food related technologies from both corporate and startup perspectives. Past Head of Development at Adama Agricultural Solutions. Scouted for Bayer Crop Science & Trendlines Fund. Co-Founder of AgChimedes.

Dr. Sergey Bujanover

Dr. Sergey Bujanover

CTO

PhD Molecular Virology, BA Medicine, MSc Pharmacology

A highly skilled scientist with extensive experience in Microbiology, Molecular Biology, Proteomics, Immunology, Tissue Culture and Biodistribution studies in animals, in addition to unparalleled experience in working with phages.

Dorin Elkabetz

Dorin Elkabetz Levin

Head of Microbiology

Dorin Elkabetz Levin, Head of Microbiology at Sustained Therapies, is a skilled scientist with expertise in molecular and microbiology. Their passion for discovery drives them to excel as a fast learner and self-motivated team player, adept at managing diverse projects independently or collaboratively. Leading the microbiology segment of product R&D, Dorin specializes in growing bacteria and phage cultures, refining assays, and fostering collaborations with local and global partners. Additionally, they manage lab operations, ensuring seamless stock and equipment management to facilitate groundbreaking research

Mordechai Tor

Mordechai Tor

Process Engineer

Mordechai Tor is a professional with a comprehensive background in Bio-process Engineering, complemented by a profound commitment to pioneering innovative bioprocessing solutions. Possessing a B.Sc. in Biotechnology Engineering, Mordechai epitomizes the ideal combination of academic prowess and practical expertise sought after by our team. His steadfast dedication as a process engineer, coupled with his amiable demeanor, renders him an invaluable and esteemed member of our organization.

Contact Sustained Therapies